Genomic ancestry evaluated by ancestry-informative markers in patients with sickle cell disease
نویسندگان
چکیده
منابع مشابه
Genomic ancestry evaluated by ancestry-informative markers in patients with sickle cell disease.
The β(s) mutation is responsible for the most aggressive form of sickle cell disease, has a predominantly African origin, and arrived in Brazil through the slave trade. However, the Brazilian population is highly miscegenated, underscoring the importance of ancestry-informative markers (AIMs) for the identification of the genetic structure of a population. In this study, we have estimated the g...
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The population of Argentina has already been studied with regard to several genetic markers, but much more data are needed for the appropriate definition of its genetic profile. This study aimed at investigating the admixture patterns and genetic structure in Central Argentina, using biparental markers and comparing the results with those previously obtained by us with mitochondrial DNA (mtDNA)...
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Autosomal ancestry informative markers (AIMs) are useful for inferring individual biogeographical ancestry (I-BGA) and admixture. Ancestry estimates obtained from Y and mtDNA are useful for reconstructing population expansions and migrations in our recent past but individual genomic admixture estimates are useful to test for association of admixture with phenotypes, as covariate in association ...
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From the Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD (C.N.R.); and the Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City (L.B.J.). Address reprint requests to Dr. Rotimi at the National Institutes of Health Center for Research on Genomics and Global Health, 12 South...
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ژورنال
عنوان ژورنال: Genetics and Molecular Research
سال: 2016
ISSN: 1676-5680
DOI: 10.4238/gmr.15017604